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Caffeine is an additive in some over-the-counter OTC painkillers, but alcohol does not have any adverse effect on it. One group received a single dose of 5ml,kg of 1 percent Tween 80; two groups each received a single dose of the antidepressant alone alprazolam, 5mg,kg; imipramine, 10mg,kg; two groups each received a single dose of the calcium channel blocker nifedipine, 5mg,kg; verapamil, 10mg,kg; four groups each received a single dose of the calcium channel blocker followed by a single dose of the antidepressant with same doses used for either in the previous four groups.In each experiment, the mice were divided into six groups n whereas online alprazolam of. FST immobility is reduced by different treatments known to be effective in depression 2, 1.